How engineered microbes could help feed the world’s crops
Fertilizer is a big deal for growing food, but making it uses tons of energy and creates lots of pollution. Some companies think tiny microbes—living things too small to see—might be the answer to a cleaner, cheaper way to feed crops.
Here's the problem: plants need nitrogen to grow, but they can't use the nitrogen in the air (which is about 80% nitrogen). Instead, they need a special form called "fixed nitrogen," like ammonia. In nature, some microbes can do this fixing. Farmers have used manure for thousands of years, and more recently, they've used synthetic fertilizers made in factories through a process called Haber-Bosch. That process uses natural gas and creates about 2% of the world's greenhouse-gas emissions. Plus, with recent energy price spikes (like those from the Iran war), fertilizer costs have gone up, hurting farmers.
So, some startups are trying to use engineered microbes to help crops get nitrogen naturally. The idea is to put these microbes in the soil around a plant's roots. They would produce ammonia for the plant, reducing the need for chemical fertilizer.
But there's a catch: making and releasing ammonia takes a lot of energy for a microbe. If they spend all their energy on that, they can't grow and multiply well. It's like if you spent all your energy doing homework and had none left for sports or hanging out.
One company, Switch Bioworks, is trying a clever solution. They're using a "genetic switch"—a piece of DNA that can turn genes on or off. Their idea is to let the microbes grow and establish a big colony first, then flip the switch so they start making ammonia. The switch could be triggered when the nitrogen level in the soil drops, so the microbes only start producing when the plant actually needs it.
Switch is testing its product in six US states, focusing on corn, which is the most planted crop in the US (over 90 million acres in 2026). Early results look promising—some corn plants treated with their microbes look healthier than untreated ones. But it's still two to three years away from being sold. "It's too early to tell exactly how well this works in the field," says CEO Tim Schnabel.
Another company, Pivot Bio, has been working on this since 2011 and already uses its products on millions of acres. They've expanded beyond corn to cotton, wheat, and other grains. Their goal is to make microbes that are tough and can survive in different environments.
Experts are cautiously excited. "There's a lot of potential for these companies and products to help farmers reduce emissions," says Dan Blaustein-Rejto, a food and agriculture expert. "This could be a really important solution for a quite hard-to-abate sector." But he warns that independent trials are key, because there's often a big gap between what a company claims and what independent researchers find.
However, there's a limit to how much fertilizer microbes can replace. Switch thinks maybe 50% is the max, and their first product might replace about 25%. Pivot says its products can also replace about a quarter. So synthetic fertilizer won't disappear anytime soon. As Blaustein-Rejto puts it, "There is no clear and plausible vision for replacing it entirely in the foreseeable future."
Still, reducing fertilizer use by even 25% would be a huge win for the environment and for farmers' wallets. As one professor, John Havlin, says, "I'm very excited about the future of the use of these products. They'll eventually have a role to play to reduce the load of nitrogen that's being applied."